Help! Please Register
where do we get antibiotics_ there?
  Drugs

  Introduction
  Medical
  Veterinary
  Environmental
  Industrial
  Agricultural


  The Fungi

  Introduction
  Descriptions
  Synonyms
  Image Bank
  Lecture Bank
  Video Bank


  Mycoses

  Introduction
  Human
  Veterinary
  Environmental
  Industrial
  Agricultural


  Laboratory

  Introduction
  Susceptibility
  MIC Database
  Procedures
  Histopathology


  Education &
  Tools

  Introduction
  Abbreviations
  Links
  CME
  Conference
  Highlights
  Bibliography
  Glossary
  Good Books
  Events
  Calendar


  About Us

  Introduction
  Our Mission
  Editorial Board
  Editorial Staff
  Supporters
  Contributors
  Legal Stuff
  Privacy Policy
  Kudos



Смотрите информацию massage manhattan здесь.
This page updated:
1/27/2007 9:23:00 AM


DoctorFungus - All Rights Reserved © 2007 Copyright
& Privacy Policy


Site built and designed for doctorfungus by Webillustrated



You are here: Drugs > Medical >
  Content Director:  
Russell E. Lewis, Pharm.D. 
Russell E. Lewis, Pharm.D.  
Butenafine

Manufacturer's Prescribing Information

Trade & Generic Names & General Features

Butenafine (N-4-tert-butylbenzyl-N-methyl-1-naphthalenemethyl-amine hydrochloride) is a benzylamine derivative and a new generation topical antifungal compound. It has favorable activity against various dermatophytes, as well as Candida albicans. Butenafine achieves high concentrations in skin and remains in skin tissue for prolonged periods (24 hours in guinea pigs). It is mostly distributed in epidermis. A small amount is detectable also in dermis, probably due to its transport via sebaceous glands and hair follicles. Importantly, butenafine exerts anti-inflammatory as well as antifungal activity in vivo. This property is particularly beneficial in dermatophytic infections that are accompanied by a marked inflammatory reaction in the infected tissue. Butenafine is soluble in water as well as in methanol, ethanol, dichloromethane, and chloroform [1502, 1606, 2210].

Butenafine has 1% cream formulation. It is being manufactured by Penederm, Inc. and its trade name is Mentax.

butenafine structure

Mechanism(s) of Action

Similar to allylamines, butenafine inhibits ergosterol biosynthesis by blocking squalene epoxidation [2210].

Susceptibility Patterns

It is mainly active against dermatophytes. The most striking feature of butenafine is its superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, tolnaftate, clotrimazole, and bifonazole. It is active also against Candida albicans and this activity is superior to that of terbinafine and naftifine. Butenafine also generates low MICs for Cryptococcus neoformans and Aspergillus spp. as well [1104, 1400, 1502, 2210].

Optional in vitro susceptibility testing parameters for butenafine remain have not been defined. However, there are some in vitro data reported. Butenafine yields lower MICs and MFCs for Microsporum canis, Microsporum gypseum, Trichophyton mentagrophytes, Trichophyton rubrum and Epidermophyton floccosum compared to naftifine, tolnaftate and clotrimazole [1502, 2210].

For butenafine MICs obtained for various types of fungi, see susceptibility patterns and the susceptibility database.

Usual Doses

Butenafine cream is applied once or twice daily on the infected area. Duration of therapy varies with anatomic location of the infection. In tinea pedis, tinea cruris or tinea corporis, 2 to 4 weeks of therapy is most common [900, 945].

Side-Effects

Topical butenafine is well-tolerated and adverse reactions are rare. Mild burning sensation at the application site has been observed in some patients [1321, 2210].

Routes

Butenafine is available for topical administration in 1% cream formulation.

Current Status

Butenafine appears as an alternative for treatment of various dermatophytosis, such as tinea pedis, tinea cruris, tinea corporis, and onychomycosis. Its rapid and persistent antifungal activity is attractive [900, 1321, 1502, 2036, 2210, 2260].

While oral antifungal therapy is still the treatment of choice for onychomycosis [945], the efficacy of several topical agents, as well as butenafine, is being investigated for this particular setting. The efficacy of butenafine in combination with Melaleuca alternifolia (tea tree) oil has been investigated in patients with toenail onychomycosis. The cream formulation consisting of 2% butenafine hydrochloride and 5% Melaleuca alternifolia (tea tree) oil achieved clinical cure in 80% of the patients after 16 weeks [2211]. Similarly, application of 2% butenafine and 20% urea incorporated in cream formulation leaded to clinical improvement in 73.3% of the patients with big toenail onychomycosis [2209].




References

900. Greer, D. L., J. Weiss, D. A. Rodriguez, A. A. Hebert, and J. M. Swinehart. 1997. A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine, a new antifungal agent. J Am Acad Dermatol. 37 (2 pt 1):231-235.

945. Gupta, A. K., T. R. Einarson, R. C. Summerbell, and N. H. Shear. 1998. An overview of topical antifungal therapy in dermatomycosis. A North American perspecitve. Drugs. 55:645-674.

1104. Iwatani, W., T. Arika, and H. Yamaguchi. 1993. Two mechanisms of butenafine action in Candida albicans. Antimicrob. Agents Chemother. 37:785-788.

1321. Lesher, J. L. J., D. E. Babel, D. M. Stewart, T. M. Jones, L. Kaminester, M. Goldman, and J. S. Weintraub. 1997. Butenafine 1% cream in the treatment of tinea cruris: a multicenter, vehicle controlled, double-blind trial. J Am Acad Dermatol. 36 (2 pt 1):S20-S24.

1400. Maeda, T., M. Takase, A. Ishibashi, T. Yamamoto, K. Sasaki, T. Arika, M. Yokoo, and K. Amemiya. 1991. Synthesis and antifungal activity of butenafine hydrochloride (KP-363), a new benzylamine antifungal agent. Yakugaku Zasshi. 111:126-137.

1502. McNeely, W., and C. M. Spencer. 1998. Butenafine. Drugs. 55:405-412.

1606. Nahm, W. K., I. Orengo, and T. Rosen. 1999. The antifungal agent butenafine manifests anti-inflammatory activity in vivo. J Am Acad Dermatol. 41 (2 pt 1):203-206.

2036. Savin, R., R. L. De villez, B. Elewski, S. Hong, T. Jones, N. Lowe, A. Lucky, B. Reyes, D. Stewart, and I. Willis. 1997. One-week therapy with twice daily butenafine 1% cream versus vehicle in the treatment of tinea pedis: a multicenter, double-blind trial. J Am Acad Dermatol. 36 (2 pt 1):S15-S19.

2209. Syed, T. A., O. A. Ahmadpour, S. A. Ahmad, and S. Shamsi. 1998. Management of toenail onychomycosis with 2% butenafine and 20% urea cream: a placebo-controlled, double-blind study. J Dermatol. 25:648-652.

2210. Syed, T. A., and H. I. Maibach. 2000. Butenafine hydrochloride: for the treatment of interdigital tinea pedis. Expert Opin Pharmacother. 1:467-473.

2211. Syed, T. A., Z. A. Qureshi, S. M. Ali, S. Ahmad, and S. A. Ahmad. 1999. Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia (tea tree) oil in cream. Trop Med Int Health. 4:630.

2260. Tschen, E., B. Elewski, D. C. Gorsulowsky, and D. M. Pariser. 1997. Tretment of interdigital tinea pedis with a 4-week-once-daily regimen of butenafine hydrochloride 1%cream. J Am Acad Dermatol. 36 (2 pt 1):S9-S14.



  Home | Image Bank | Lecture Bank | Knowledgebase | Site Map | Contact Us |
The Fungi | Mycoses | Drugs |
Laboratory | Education & Tools | About Us

  mycosesstudygroup.org's sponsors